Eventos Anais de eventos
ENEBI 2018
6º Encontro Nacional de Engenharia Biomecânica
MULTISCALE REMODELING MODEL FOR ORTHODONTIC MOVEMENT CONSIDERING CELLULAR CEMENTUM
Submission Author:
Emílio Mercuri , PR
Co-Authors:
Emílio Mercuri, Mildred Ballin Hecke
Presenter: Emílio Mercuri
doi://10.26678/ABCM.ENEBI2018.EEB18-0197
Abstract
Remodeling is responsible for the removal of the micro-damage and consequently the increase in the useful life of a mineralized tissues. Continuum micromechanics was chosen to characterize the hierarchical, anisotropic, heterogeneous and multiscale constitutive behaviour of the bone and cementum. A dynamic interaction model was adopted to describe the cellular interactions and the influence of paracrine signaling on the millimeter-sized representative volume element. The homogenization procedure can provide the macroscopic mechanical properties based on the composition of the microstructure of the material. A computer code, entitled Remold 2D, was developed and programmed in MATLAB. The spatial discretization of the two-dimensional geometries was performed using the Finite Element Method and the temporal evolution of biological variables and volume fractions was solved by the fourth-order Runge-Kutta method. The theory was applied in the orthodontic movement of a central incisor. The mechanical stimulus used to trigger cellular activity is the strain energy density at the microscale. The results show the temporal evolution of the microstrain energy density distribution in the bi-dimensional model. This distribution was shown to be in agreement when compared with other models in the literature. The study is a first step in the development of other studies related to the imbalance of bone homeostasis and the use of drugs in the treatment of bone diseases.
Keywords
Cementoblasts, Cementoclasts, multiscale modeling, remodeling, Orthodontics
