Eventos Anais de eventos
ENEBI 2018
6º Encontro Nacional de Engenharia Biomecânica
MICRO-FINITE ELEMENT ANALYSIS OF HIERARCHICAL LAYERS OF THE ARTICULAR CARTILAGE FOR BIOFABRICATION
Submission Author:
Janaina Dernowsek , SP , Brazil
Co-Authors:
Janaina Dernowsek, Henrique Takashi Idogava, Monize Decarli, daniel kemmoku, Pedro Noritomi, Jorge Vicente Lopes da Silva
Presenter: Janaina Dernowsek
doi://10.26678/ABCM.ENEBI2018.EEB18-0165
Abstract
The biofabrication of engineered tissues is an essential area to reconstruct tissues. Until now, to the best of our knowledge, it has not been possible to mimic the biological and biochemical properties. New approaches to developing a new tissue become an attractive target for bioprinting, which is emerging as an essential strategy to recreate the histoarchitecture and the relationship between cells, matrix, and microenvironment. Simulations in a microscale study is a crucial factor to understand specifics properties. The objective is to analyze the impact of stress on the hierarchical layers of the cartilage using finite element method. The interaction of the collagen fibers with the chondrocyte was observed through the contact regions of the principal minimal stress analysis, mainly in the region of contact between chondrocytes. The deformation corresponds to the condition of constraint and applied force. The results are promising for future simulations of more detailed models with bias in vivo and in vitro.
Keywords
Micro-finite element method, Articular cartilage, Biofabrication., computer simulations, Biomechanics.
