Eventos Anais de eventos
COBEM 2021
26th International Congress of Mechanical Engineering
COMPUTATIONAL STUDY OF ELECTRIC FIELD TREATMENT AT BONE-NEIGHBORING TUMORS
Submission Author:
Daniella de Lourdes Luna Santana de Andrade , PE
Co-Authors:
Pedro José Teixeira Pagano, Jéssica Rodrigues , Daniella de Lourdes Luna Santana de Andrade, Guilherme Brasil Pintarelli, Jennifer Rodrigues, Daniela Suzuki
Presenter: Daniella de Lourdes Luna Santana de Andrade
doi://10.26678/ABCM.COBEM2021.COB2021-1139
Abstract
Electrochemotherapy success is directly related to tumor electric field coverage, and the coverage failure may result in tumor recurrence and pain. The electric field may diffract during nodule treatment due to surrounding dielectrics and non-linear dynamic response to electroporation. Computational models are used to study this complex process and optimize the treatment. Bone is characterized as a low electric conductivity material, and if located near tumor regions, it may affect the electric field distribution. This paper aims to assess the electric field distribution in cancer-infected tissue near bones. We calculated the electric field distribution using computational simulations (COMSOL Multiphysics). Our case study was a dogs' nasal cavity tumor surrounded by bone (semi ellipsoid). We investigated whether the voltage pulses would meet electrochemotherapy electric field requirements. This is, minimizing the lack of an insufficient electrical field, the so-called indentation. We studied a range of 282.4 to 529.5 V applied to a recently ECT electrode apparatus. We also studied if a conductive gel could enhance the electrical field distribution. Results showed that high electric field application does not solve the indentation problem. The electric field indentation was detected from approximately 3 mm electrode-bone proximity region at the lowest electric fields and increased to 5 mm at 150 kV/m. The electric field indentation mostly occurred due to the bone insulator behavior. The use of the conductive gel also led to indentation. The tumor volume coverage is reduced when compared with simulations without gel, thus it is not recommended for use in this situation.
Keywords
Electrochemotherapy, Electromechanical properties of tissues, Cancer treatment, ESOPE, Complex geometry problems
