Eventos Anais de eventos
COBEM 2021
26th International Congress of Mechanical Engineering
Mechanical and biological evaluation of the Graphene / nanohydroxyapatite composite for application in bone tissue engineering
Submission Author:
José Victor Passos Santiago , MG
Co-Authors:
José Victor Passos Santiago, Viviane Gomide, Thuany Silva, Juliana Lott de Carvalho
Presenter: José Victor Passos Santiago
doi://10.26678/ABCM.COBEM2021.COB2021-0421
Abstract
Loss of tissue or organs caused by injury or disease is a serious health problem that negatively affects the patient’s life. Tissue engineering utilizes different scaffold materials to control cell proliferation, differentiation and to stimulate the extracellular matrix. In this context, Graphene-based materials have led to new approaches to regenerative medicine and tissue engineering. For instance, bone tissue engineering is a promising solution for faster healing and for reconstruction of large bone defects, graphene and its derivatives having a wide range of applications in this sense. The objective of the present work is to synthesize and evaluate the mechanical properties and cytotoxicity of the composite graphene/ nanohydroxyapatite by the diametrical compression test, Vickers microhardness, Scanning Electron Microscopy and in vitro evaluation of the composite cytotoxicity over primary human dermal fibroblasts. It was found that the ceramic processing was adequate due to the low amount of pores and therefore, high densification when analyzed by SEM. Regarding the mechanical properties, it was observed that the fracture toughness and hardness increased with the graphene content. In vitro results showed that the composite can provide a satisfactory environment for human cells.
Keywords
biomaterials, graphene, nanohydroxyapatite, Bone Tissue
