Eventos Anais de eventos
ENCIT 2022
19th Brazilian Congress of Thermal Sciences and Engineering
Effect of Nanoparticle Biodistribution in the Laser Induced Thermal Therapy: a Skin Cancer Embedded with Gold Nanoshells
Submission Author:
Ícaro Kleisson Araújo Lucena , RN
Co-Authors:
Ícaro Kleisson Araújo Lucena, Andre Maurente
Presenter: Andre Maurente
doi://10.26678/ABCM.ENCIT2022.CIT22-0265
Abstract
The main objective of this study is to evaluate the effects caused by the variation of nanoparticles, after their deposition, in the tissue, verifying the possible changes in the heat flux and in the tissue ttemperature profile. A Skin cancer, diameter of 100 mm and thickness of 36 mm, with five layers (epidermis, tumor, papillary and reticular dermis and fat), for 10s, was irratiated by a helium-neon laser (laser power of 20 kW/m2 and wavelength is 0.6328 μm). Slabs are one-dimensional and embedded with Silica-gold nanoshells (GNS) with following dimensions: r=10 nm (shell) and 0.725r (silica core), the volume fraction used was 10-5 particles. Numerical study used Monte Carlo and Finite volume approaches to solve the problem involving conduction, blood perfusion and radiation. Two spatial configurations are compared with uniform case: (I) GNS accumulated on epidermis and first half by the tissue and (II) GNS accumulated on tumour periphery. Case 1 produced a temperature profile sufficient to cause necrosis of cancerous tissues and mitigate damage to healthy areas, validated the importance of considering the position of nanoparticles as a key parameter in numerical studies, making it a probable variable, in the future, on in vivo, in vitro and clinical tests.
Keywords
GNS, biodistribution, Monte Carlo, Finite Volume, skin
