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ENCIT 2020
18th Brazilian Congress of Thermal Sciences and Engineering
IMPROVED ANISOTROPIC TRANSPORT THROUGH POLYMER LAYER AND POROUS ARTERIAL WALL WITH BINDING IN DRUG-ELUTING STENTS
Submission Author:
fabiane aparecida dos santos frazzoli , RJ
Co-Authors:
fabiane aparecida dos santos frazzoli, Haroldo Rosman Junior, Rachel Manhães de Lucena, Norberto Mangiavacchi, José da Rocha Miranda Pontes, Gustavo Rabello dos Anjos, Sean McGinty
Presenter: fabiane aparecida dos santos frazzoli
doi://10.26678/ABCM.ENCIT2020.CIT20-0622
Abstract
Dissolution in the polymer coating and specific binding in the artery wall play an important role in anisotropic transport of the antiproliferative/anti-inflammatory drugs. In this work, we consider the model of dissolution, transport and binding of sirolimus on an axisymmetric domain representing the polymer coating layer and the porous artery wall in the vicinity of a stent strut. The Finite Element Method (FEM) is used to discretize the porous media equations by an interconnected unstructured triangular mesh and an improved anistropic model is employed to accurately capture the correct effect of the diffusion tension seem in the sirolimus concentration distribution. Finally, we present the new results obtained to the characterization of the dynamics of the porous arterial wall with binding in drug-eluting stents.
Keywords
drug-eluting stents, Darcy flow, Convection Diffusion Equations, Finite Element Method
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