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ENCIT 2020
18th Brazilian Congress of Thermal Sciences and Engineering
INVERSE DESIGN OF HEAT SOURCE PATTERNS FOR TUMOR TREATMENTS VIA HYPERTHERMIA
Submission Author:
João Bragança , RJ , Brazil
Co-Authors:
João Bragança, Julia Burgani, César Cunnha Pacheco
Presenter: João Bragança
doi://10.26678/ABCM.ENCIT2020.CIT20-0058
Abstract
In this work, the optimal design of heat sources for hyperthermia treatment of tumors in a realistic 3D brain geometry is performed. This problem is recast by means of an inverse design problem, where the Pennes Bioheat Transfer Equation is used as the forward problem. The inverse problem is solved by defining an ideal temperature distribution, in which a small temperature increase is present within the tumor region. The mathematical model, as well as the desired temperature profile, are manipulated in terms of temperature increase, instead of absolute temperature, simplifying the analysis. The brain model contains an intraventricular tumor and was obtained from magnetic resonance images (MRI). The Pennes equation is solved using OpenFOAM, while the inverse problem is solved using the Levenberg-Marquardt method. This methodology is also very versatile, allowing for different heating models to be selected, including ultrasound heating, which is considered as one of the methods of choice for hyperthermia. It also allows for medical professionals to design patient-specific thermal doses, improving the success rate of the treatment.
Keywords
bioheat transfer, inverse design, numerical solution, tumor treatment, ultrasound heating
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